人体解剖学 教授
职称：教授
学科专业：人体解剖学
研究方向：认知、情绪及发育障碍的神经环路和突触可塑性机制
行政职务：人体解剖学系主任；认知与发育障碍神经科学创新实验室主任
电子邮箱：tgqguo@jnu.edu.cn
个人介绍：郭国庆，研究生学历，博士学位，教授，博士导师，解剖学系主任。1989年毕业于河南新乡医学院；1995年中山医科大学获硕士学位，师从解剖学家邝国璧教授；2007年南方医科大学获博士学位，师从解剖学家钟世镇院士；2003年受聘为太阳城集团医学院副教授、硕士生导师，2010年受聘教授、博士生导师。一直从事人体解剖学的教学和科研工作，研究兴趣在于用形态学、分子生物学、光遗传学、在体电生理、细胞和脑片膜片钳以及行为学等技术解析认知与发育障碍相关神经系统疾病的环路机制及树突棘可塑性机制。主持国家自然科学基金3项，广东省自然科学基金3项、省重点项目1项、其他各类科学基金9项；以通讯作者发表在Neuropsychopharmacology、Translational Psychiatry、Neurobiology of Disease等国际期刊发表SCI论文40余篇，获河南省教育厅科技二等奖1项。
座右铭：科学研究需要兴趣，也需要耐心、踏实和努力。
2010.10-至今，广州太阳城集团医学院解剖学系，教授
2004.09-2007.06，广州南方医科大学基础医学院人体解剖学专业，获医学博士学位
1995.07-2010.10，广州太阳城集团医学院解剖学系，助教，讲师，副教授
1992.09-1995.06，广州中山医科大学人体解剖学专业，获医学硕士学位
1989.07-1992.08，河南新乡医学院基础医学部，助教
1984.09-1989.06，河南新乡医学院临床医学系儿科专业，获医学学士学位
[1] Li F#, Zheng X#, Wang H, Meng L, Chen M, Hui Y, Liu D, Xie K, Zhang J*, Guo G*. Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors. Neuropsychopharmacology. 2024. https://doi.org/10.1038/s41386-024-01829-y.
[2] Zhang W#, Zhang J#, Zhang Z#, Cha S, Li J, Chen L, Wu J, Teng J, Guo G*, Zhang J*. Effects of deSUMOylated spastin on AMPA receptor surface delivery and synaptic function are enhanced by phosphorylating at Ser210. Mol Neurobiol. 2024. doi: 10.1007/s12035-024-03935-w.
[3] Zhang H#, Yu G#, Li J#, Tu C, Hui Y, Liu D, Chen M, Zhang J*, Gong X*, Guo G*. Overexpressing lnc240 rescues learning and memory dysfunction in hepatic encephalopathy through miR-1264-5p/MEF2C axis. Mol Neurobiol. 2023, 60(4): 2277-2294.
[4] Chen M#, Jiang Y#, Li X#, Li J, Tu C, Zhang H, Gong X, Yu G*, Guo G*, Zhang J*. Enriched environment ameliorates learning and memory deficits in hepatic encephalopathy mice by restoration of the structure of dendrites and dendritic spines. Brain Res. 2023, 1804: 148264.
[5] Wang H#, Li F#, Zheng X#, Meng L, Chen M, Hui Y, Li Y, Xie K, Zhang J*, Guo G*. Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice. Transl Psychiatry. 2022, 12(1):380.
[6] Zhu W#, Wu F#, Li J, Meng L, Zhang W, Zhang H, Cha S, Zhang J*, Guo G*. Impaired learning and memory generated by hyperthyroidism is rescued by restoration of AMPA and NMDA receptors function. Neurobiol Dis. 2022, 171:105807.
[7] Zhang J#, Zilundu PLM#, Fu R, Zheng X, Zhou L*, Guo G*. Medical students' perceptions and performance in an online regional anatomy course during the Covid-19 pandemic. Anat Sci Educ. 2022, 15(5):928-942.
[8] Zhang J#,, Zilundu PLM#,, Zhang W#,, Yu G, Li S, Zhou L*, Guo G*. The use of a surgical boot camp combining anatomical education and surgical simulation for internship preparedness among senior medical students. BMC Med Educ. 2022, 22(1): 459.
[9] Zhu W#, Wu F#, Hu J, Wang W, Zhang J*, Guo G*. Structural investigation of the interaction mechanism between chlorogenic acid and AMPA receptor via in silico approaches. Molecules. 2022, 27(11): 3394.
[10] Zhang H#, Zhang W#, Yu G#, Li F, Hui Y, Cha S, Chen M, Zhu W, Zhang J*, Guo G*, Gong X*. Comprehensive analysis of lncRNAs, miRNAs and mRNAs in mouse hippocampus with hepatic encephalopathy. Front Genet. 2022, 13:868716.
[11] Hui Y#, Zheng X#, Zhang H#, Li F, Yu G, Li J, Zhang J*, Gong X*, Guo G*. Strategies for targeting neural circuits: how to manipulate neurons using virus vehicles. Front Neural Circuits. 2022,16: 882366.
[12] Cheng L#, Chen K#, Li J#, Wu J, Zhang J, Chen L, Guo G*, Zhang J*. Phosphorylation of CRMP2 by Cdk5 negatively regulates the surface delivery and synaptic function of AMPA receptors. Mol Neurobiol. 2022, 59(2): 762-777.
[13] Chen L#, Wang H#, Cha S#, Li J, Zhang J, Wu J, Guo G*, Zhang J*. Phosphorylation of spastin promotes the surface delivery and synaptic function of AMPA receptors. Front Cell Neurosci. 2022, 16:809934.
[14] Li S#, Zhang J#, Zhang J#, Li J, Cheng L, Chen L, Cha C*, Guo G*. Spastin interacts with CRMP2 to regulate neurite outgrowth by controlling microtubule dynamics through phosphorylation modifications. CNS Neurol Disord Drug Targets, 2021, 20(3):249-265.
[15] Zhang J#, Zilundu PLM, Zhou L, Guo G*. Supplementary regional anatomy teaching by surgeons enhances medical students mastery of anatomical knowledge and positively impacts their choice of future career. J Surg Educ. 2020, 77(5):1113-1120.
[16] Zhang J#, Li J#, Yin Y#, Li X, Jiang Y, Wang Y, Cha C*, Guo G*. Collapsin response mediator protein 2 and endophilin2 coordinate regulation of AMPA receptor GluA1 subunit recycling. Front Mol Neurosci, 2020, 13: 128.
[17] Ji Z#, Liu Q#, Zhang J, Yang Y, Li J, Zhang G, Tan M*, Lin H*, Guo G*. SUMOylation of spastin promotes the internalization of GluA1 and regulates dendritic spine morphology by targeting microtubule dynamics. Neurobiol Dis. 2020, 146:105133.
[18] Li J#, Wu F#, Cheng L, Zhang J, Cha C, Chen L, Feng T, Zhang J*, Guo G*. A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule severing function. Mol Med Rep. 2020, 21(6): 2367-2374.
[19] Zhang Z#, Zhang J#, Li J, Zhang J, Chen L, Li Y*, Guo G*. Ketamine regulates phosphorylation of CRMP2 to mediate dendritic spine plasticity. J Mol Neurosci, 2020, 70(3): 353-364.
[20]Wang C, Huang X, Wu Y, Wang J, Li F*, Guo G*. Tumor cell-associated exosomes robustly elicit anti-tumor immune responses through modulating dendritic cell vaccines in lung tumor. Int J Biol Sci. 2020, 16(4):633-643.
[21] Yin Y#, Cha C#, Wu F, Li J, Li S, Zhu X, Zhang J*, Guo G*. Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β. Mol Med Rep, 2019, 19(6): 4897-4905.
[22] Zhang J#, Zhao B#, Zhu X#, Li J, Wu F, Li S, Gong X, Cha C*, Guo G*. Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines. Brain Res Bull. 2018, 139: 21-30.
[23] Zhang J#, Yin Y#, Ji Z, Cai Z, Zhao B, Li J, Tan M*, Guo G*. Endophilin2 interacts with GluA1 to mediate AMPA receptor endocytosis induced by oligomeric amyloid-β. Neural Plast, 2017, 2017：8197085.
[24] Cha C#, Zhang J#, Ji Z, Tan M, Li S, Wu F, Chen K, Gong S, Guo G*, Lin H*. CRMP4 regulates dendritic growth and maturation via the interaction with actin cytoskeleton in cultured hippocampal neurons. Brain Res Bull, 2016, 124: 286-94.
[25] Zhang J#, Tan M#, Yin Y, Ren B, Jiang N, Guo G*, Chen Y*. Distinct functions of endophilin isoforms in synaptic vesicle endocytosis. Neural Plast. 2015, 371496.
1.《系统解剖学》. 华中科技大学出版社，2023年.（主编）
2.《系统解剖学实验教程》华中科技大学出版社，2023年.（副主编）
3.《人体解剖生理学》. 北京大学医学出版社，2020年.（主编）
4.《系统解剖学实验指导》.北京大学医学出版社，2018年.（主编）
5.《Grant解剖学操作指南》(第17版). 北京科学技术出版社，2022年. (参译)
6.《系统解剖学》(第2版). 高等教育出版社，2020年. (参编)
7.《系统解剖学》. 世界知识出版社，2002年. (参编)
8.《系统解剖学学习指导》. 世界知识出版社，2002年. (参编)
9.《系统解剖学》. 高等教育出版社，2014年. (参编)
10.《科技文献检索与利用》 科学出版社，2014年. (参编)
11.《Grant解剖学操作指南》(第15版). 北京科学技术出版社，2016年. (参译)
1.第十届太阳城集团高等公司产品成果特等奖，第一完成人
2.广东省线下一流本科课程《系统解剖学》，负责人
3.外科医生走进局部解剖学课堂有助于知识掌握和未来职业规划, 获得全国高等院校第五届实验教学及实验技术工作者优秀论文一等奖（通讯作者）
广东省精准医学应用学会数字医学分会 副主任委员
广东省解剖学会第十四届理事会 常务理事
中国临床解剖学杂志 编委
中国解剖学会第十七届理事会虚拟现实分会 常务委员
中国医师协会显微外科医师分会第二届委员会显微基础研究学组 委员
广东省神经科学学会 理事
