免疫学 研究员
职称：研究员
学科专业：免疫学
研究方向：
1、皮肤免疫
2、天然免疫抗病毒研究
电子邮箱：lianghuab@yahoo.com
2014.07-至今，太阳城集团，生物医学转化研究院，研究员，博导
2013.01-2014.07，中南大学，遗传国家重点实验室，教授
2007.08-2012.12，美国国立犹太医院儿科系，助理教授
2005.05-2007.07，美国科罗拉多大学医学院药理系，研究助理
2000.07-2005.04，美国国立犹太医学与研究中心免疫系，博士后
1997.09-2000.06，中南大学，肿瘤研究所病理学与病理生理学专业，博士
1995.07-1997.08，中南大学基础医学院病理教研室，助教
1992.09-1995.06，中南大学，基础医学院病理教研室病理学专业，硕士
1987.09-1992.06，中南大学，湘雅医学院临床医学系临床医学专业，学士
1.Lianghua Bin(#), LiehuaDeng, HengwenYang, LeqingZhu, XiaoWang, Michael G.Edwards, Brittany Richers, DonaldY. M.Leung, Forkhead Box C1Regulates HumanPrimary Keratinocyte TerminalDifferentiation, PLoS One, 2016, 11(12): e0167392.
2.Li Gao(#),Lianghua Bin(#), Nicholas M. Rafaels, Lili Huang, Joseph Potee, Ingo Ruczinski, Terri H. Beaty, Amy S. Paller, Lynda C. Schneider, Rich Gallo, Jon M. Hanifin, Lisa A. Beck，Raif S. Geha, Rasika A. Mathias, Kathleen, C. Barnes, Donald Y.M. Leung, Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicatedby eczema herpeticum, Journal of Allergy and Clinical Immunology, 2015, 136(6): 1591-1600.
3.Lianghua Bin(#), Michael G. Edwards, Ryan Heiser，Joanne E.， Streib，Brittany Richers，Clifton F. Hall, Donald Y.M. Leung, Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum，Journal of Allergy and Clinical Immunology, 2014, 134(4): 848-855.
4.Brauweiler AM(#), Lianghua Bin (#), Kim BE, Schlievert PM, Oyoshi MK, Geha RS, Goleva E, Leung DYM*, Filaggrin dependent secretion of sphingomyelinase protects against Staphylococcal alpha toxin induced keratinocyte death, Journal of Allergy Clinical Immunology, 2013, 131:421-7.
5.Lianghua Bin (#), Kim BE, Brauweiler A, Goleva E, Streib J,Ji Y, Schlievert PM, Donald Leung DYM*, Staphylococcus aureus Alpha-toxin Modulates Skin Host Response to Viral Infection, Journal of Allergy Clinical Immunology, 2012, 130(3):683-691.e2.
6.Lianghua Bin (#), Howell MD, Kim BE, Hall CF, Streib JE, Zaccaro DJ and Leung DYM*, Specificity protein 1 is pivotal in skin’s anti-viral response, Journal of Allergy Clinical Immunology, 2011, 127(2): 430-438. e1-2.
7.Kim BE, Bin L, Ye YM, Ramamoorthy P, Leung DY. IL-25 Enhances HSV-1 replication by inhibiting Filaggrin expression, and acts synergistically with Th2 cytokines to enhance HSV-1 replication. Journal of Investigative Dermatology2013 Dec;133(12):2678-85.
8.Bin L(#), Hall C, Leung DY. Inhibition of transcription factor specificity protein 1 alters gene expression profile of keratinocytes leading to up-regulation of kallikrein-related peptidases and TSLP. Journal of Investigative Dermatology 2011 Nov; 131(11): 2213-22.
9.Menke C, Bin L, Thorburn J, Bahbakht K, Ford H, Thorburn A. Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Research 2011 Mar 1, 71(5): 1883-92.
10.Bin L(#), Howell MD, Kim BE, Hall CF, Streib JE and Leung DY.Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through down-regulation of IL-10 receptor 2 chain. Journal of Allergy Clinical Immunology 2009 Aug; 124(2): 270-7, 277.e1.
11.Howell MD, Fairchild HR, Kim BE, Bin L, Boguniewicz M, Redzic JS, Hansen KC, Leung DY, Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. J Invest Dermatol2008 Sep; 128(9):2248-58.
12.Bin L(#), Thorburn J, Thomas L and Thorburn A. Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signalling through the DR4 receptor by competing for ligand binding. J Biol. Chem. 2007 Sep 21; 282(38):28189-94.
13.Cusich JK, Xu LG, Bin LH, Han KJ, Shu HB. Indentification of RELT homologues that associate with RELT and are phosphorylated by OSR1. BiochemBiophys Res Commun. 2006, Feb 10; 340(2):535-43.
14.Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB.TRIP6 is a RIP2-associated common signaling component of multiple NF-kappa B activation pathways. J Cell Sci. 2005, 118(Pt 3):555-63.
15.Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappa B activation and apoptosis pathways. J Biol Chem. 2004, 279(15):15652-61.
16.Zhang XM, Sheng SR, Wang XY, Bin LH,Wang JR, Li GY. Expression of tumor related gene NAG6 in gastric cancer and restriction fragment length polymorphism analysis.World J Gastroenterol. 2004 May 1; 10(9): 1361-4.
17.Bin LH(#), Nielson L, Liu X, Mason R and Shu HB. Identification of Uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.J Immunol. 2003, 171: 924-930.
18.Bin LH(#), Xu L, Shu HB. TIRP: a novel TIR-domain containing adaptor protein involved in Toll/interleukin-1 receptor signaling. J BiolChem 2003, 278(27):24526-24532.
19.Bin LH(#), Li X, Xu LG, Shu HB. The short splice form of Casper/c-FLIP is a major cellular inhibitor of TRAIL-induced apoptosis. FEBS Lett. 2002, 510, 37-40.
20.Bin L(#), Li LY, Hu JC, Zha JK, Xu LG, Zhang Z, Zhai ZH, Shu HB. Recombinant solubleTRAIL induces apoptosis of cancer cells. Chinese Science Bulletin, 2001, 46(24): 2073-2077.
21.Xie Y, Bin L, Yang J, Li Z, Yu Y, Zhang X, Cao L, Li G. Molecular cloning andcharacterization of NAG-7: a novel gene downregulated in human nasopharyngeal carcinoma. Chin Med J (Engl). 2001, 114, 530-534.
22.Hu CP, Bin L, Zhan FH, Li GY. The study on the functional status of signal transduction pathway of transforming growth factor in lung cancerous cells. Chinese J Pathology. 1999,(4):197-199.
23.Zhan FH, Chao L, Bin L, Jiang N,DengLW,XieY,TanGL,Li GY. cDNA representative difference analysis of differentially expressed cDNA sequence in human nasopharyngeal carcinoma. Chinese Medical Journal 1999,(4):538-543.
24.Jiang N, Bin L, Tang XN, Zhou M, Zeng ZY, Li GY .The expression of connexin genes in nasopharyngeal carcinoma cells and the effect of retinoic acid on the regulation of those genes. Chinese Journal of Cancer Research 1999, 11:177-179.
25.Bin L(#), Qian ZF. The growth factors and lung fibrosis (review).Medicine Abroad 1997; 17(1): 19-21.
26.Bin L(#), Qian ZF. Study on heparin promoting lung fibroblasts proliferation.Chinese Journal of Clinical and Experimental Pathology.1998, 25(3):276-2
