罗钧洪

系统生物医学系主任 教授

个人简介


职称:教授

学科专业:系统生物医学

研究方向:多组学、人工智能、生物医学大数据、衰老

行政职务:系统生物医学系主任

电子邮箱:luojh@jnu.edu.cn

个人介绍:罗钧洪,医学科学博士,太阳城集团教授、博士生导师。国家引进海外高层次人才计划青年人才(第十六批),国家自然科学基金外国优秀青年学者,广东省珠江人才计划引进高层次人才,回国前曾在澳大利亚联邦科学与工业研究组织任研究员(终身制)。主要研究方向为基因组学、三维基因组学和生物信息学,长期从事生物医学大数据相关研究,专注于人工智能技术在单细胞测序、T细胞受体组库和其它生物医学多组学大数据分析中的开发和应用。在Cell、Nature、Nat Aging、Nat Genetics、Nat Protocols和STTT等顶级期刊发表30余篇学术论文,总他引超过20000次,获授权美国专利1项,国家发明专利3项。


学习经历


2007.8–2011.6,澳大利亚国立大学,医学科学,博士

2002.7–2006.6,澳大利亚新南威尔士大学,生物信息学,工程学士(Hounors degree) 


工作经历


2019.6-至今,太阳城集团,太阳成集团tyc539官网,教授

2016.8-2019.5,澳大利亚联邦科学与工业研究组织,Health & Biosecurity,研究员(Tenured)

2016.3-2016.7,美国杰克逊实验室基因组医学研究所,Genome Sciences,助理研究员

2012.9-2016.3,美国杰克逊实验室基因组医学研究所,Genome Sciences,博士后,合作导师:阮一骏

2011.7-2012.9,新加坡基因组研究所(GIS),Genome Technology and Biology,博士后,合作导师:阮一骏

2006.7-2007.7,澳大利亚悉尼大学,兽医学院,生物信息科研员


主要论文


1.Chao Ke*; Boya Huang*; Jian Xiang*; Jinlian Liang*; Guangjie Wu; Minghui Qiu; Kai Cheng; Lipeng Mao; Wen Lei; Yang Hu; Xiaogen Tang; Yizhen Tian; Guobing Chen#; Oscar Junhong Luo#; Hongyi Zhang#; Secreted Clusterin Inhibits Tumorigenesis by Modulating Tumor Cell and Macrophage in Human Meningioma, Neuro-Oncology, 2024, 26(noae034) 

2.Bei Zhang, Zhiyao Ren, Jianfu Zhao, Yue Zhu, Boya Huang, Chanchan Xiao, Yan Zhang, Jieping Deng, Lipeng Mao, Lei Tang, Dan Lan, Lijuan Gao, Hongyi Zhang#, Guobing Chen#, Oscar Junhong Luo#. (2023). Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer. Theranostics, 13(13):4449-4468.

3.Zhenghu Jia, Zhiyao Ren, Dongmei Ye, Jiawei Li, ……Guobing Chen, Peiling Li, Juan Ouyang, Peisong Chen#, Oscar Junhong Luo#, Yifang Gao# & Zhinan Yin# (2023) Immune-Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults. Phenomics, 2023 May 23.

4.Xiao, C., Ren, Z., Zhang, B., Mao, L., Zhu, G., Gao, L., Su, J., Ye, J., Long, Z., Zhu, Y., Chen, P., Su, X., Zhou, T., Huang, Y., Chen, X., Xie, C., … Zhang, H., Wang, P.#, Liang, X.#, Luo, O.J.#, Chen, G.#. (2023). Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults. Nature Aging, 3(3)

5.Lai, W., Wang, X., Liu, L., Xu, L., Mao, L., Tan, J., Zha, X., Zhan, H., Lei, W., Lan, Y., Chen, G., Li, Y.#, & Luo, O. J.# (2022). Single-cell profiling of T cells uncovers a tissue-resident memory-like T-cell subset associated with bidirectional prognosis for B-cell acute lymphoblastic leukemia. Frontiers in Immunology, 13, 7258. 

6.Luo, O. J*#., Lei, W.*, Zhu, G.*, Ren, Z.*, Xu, Y., Xiao, C., Zhang, H., Cai, J., Luo, Z., Gao, L., Su, J., Tang, L., Guo, W., Su, H., Zhang, Z. J., Fang, E. F., Ruan, Y., Leng, S. X., Ju, Z., … Chen, G. (2022). Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty. Nature Aging, 2(4), 348–364. 

7.Hu, Y., Xu, Y., Mao, L., Lei, W., Xiang, J., Gao, L., Jiang, J., Huang, L., Luo, O. J.#, Duan, J.#, & Chen, G#. (2022). Gene Expression Analysis Reveals Age and Ethnicity Signatures Between Young and Old Adults in Human PBMC. Frontiers in Aging, 2, 77. 

8.Di, B.*, Jia, H.*, Luo, O. J.*, Lin, F.*, Li, K., Zhang, Y., Wang, H., Liang, H., Fan, J., & Yang, Z. (2020). Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics. Signal Transduction and Targeted Therapy 2020 5:1, 5(1), 1–4.

9.Li, X.*, Luo, O. J.*, Wang, P., Zheng, M., Wang, D., Piecuch, E., Zhu, J. J., Tian, S. Z., Tang, Z., Li, G., & Ruan, Y. (2017). Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions. Nature Protocols, 12(5), 899–915. 

10.Tang, Z.*, Luo, O. J.*, Li, X.*, Zheng, M., Zhu, J. J., Szalaj, P., Trzaskoma, P., Magalska, A., Wlodarczyk, J., Ruszczycki, B., Michalski, P., Piecuch, E., Wang, P., Wang, D., Tian, S. Z., Penrad-Mobayed, M., Sachs, L. M., Ruan, X., Wei, C. L., … Ruan, Y. (2015). CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell, 163(7), 1611–1627. 

*共一作者  #共通讯作者


获奖及荣誉


The Jackson Laboratory Community Award,The Jackson Laboratory,2015

CSIRO Julius Award, 澳大利亚联邦科学与工业研究组织,2018

太阳成集团tyc539官网科研工作先进个人,2020、2023


学术兼职


太阳城集团第九届学术委员会委员

广东省医学会医学人工智能分会第一届委员会委员

广东省医学会老年医学分会第九届委员会老年免疫学组成员

广东省精准医学应用学会单细胞科技分会会员