病理生理学 研究员
职称：研究员
学科专业：病理生理学
研究方向：血管与血液系统发育的谱系规律及调控机制
个人简介：
现为太阳成集团tyc539官网研究员、博士生导师、太阳城集团血液学研究所副所长。入选2019年“珠江人才计划”科技创新人才。为国家自然科学基金委会议评审专家；Cell Stem Cell、Cell Research、Nat Communications、Blood 等期刊审稿人，Blood特邀专文评述撰写人。
研究方向聚焦血管与血液系统发育的谱系规律及调控机制。承担国家重点研发计划课题及国家自然科学基金重大项目课题等科研项目。近年来结合系列单细胞技术和精准谱系示踪策略，刻面了哺乳动物血管系统及包括造血干细胞在内多种血液谱系发育的全转录组表达景观及发育路径、重构了哺乳动物血管发育早期动静脉特化模式、发现生血内皮和发育造血干细胞的功能异质性、揭示了造血干细胞发生的长链非编码RNA及RNA剪接等调控新机制。通讯作者（含共同）研究论文发表在 Nature、Nature Immunology、Cell Stem Cell、Immunity、Developmental Cell、Cell Research (5篇)、Science Advances、Nature Communications、Blood (2篇)、Circulation Research等杂志。其中多篇论文配发专文评述、被F1000推荐。科研成果入选《中国2020年度重要医学进展》、连续两年(2020 及 2021)入选《中国血液学年度十大研究进屐》，参与合作成果“造血干细胞的神奇之旅”入选《国家“十三五”科技创新成就展》。
1990.08-1995.07，第三军医大学，临床医学专业，获医学学士学位
1998.08-2001.06，第二军医大学，内科学专业，获医学硕士学位
2003.08-2007.06，军事医学科学院，遗传学专业，获理学博士学位
1995.08–1998.07，海军总医院，医师
2001.07–2007.12，海军总医院，主治医师
2008.01–2011.09，军事医学科学院生物工程研究所，助理研究员
2011.09–2016.07，军事医学科学院生物工程研究所，副研究员
2017.01–至今，太阳城集团医学部基础医学院，研究员
通讯作者20篇代表性论文：
1.Changlu Xu#, Jian He#, Hongtao Wang#, Yingnan Zhang#, Jing Wu#, Lu Zhao#, Yue Li, Jie Gao, Guangfeng Geng, Bingrui Wang, Xiaoyuan Chen, Zhaofeng Zheng, Biao Shen, Yang Zeng, Zhijie Bai, Hua Yang, Shujuan Shi, Fang Dong, Shihui Ma, Erlie Jiang, Tao Cheng, Yu Lan*, Jiaxi Zhou*, Bing Liu*, Lihong Shi*. Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis. Nature Immunology. 2022. (PMID: 35761081. DOI: 10.1038/s41590-022-01245-8). Epub 2022-06-27 (2021 IF=31.250)
2.Bo Yu#, Bingyan Wu#, Pingshan Hong, Huan Peng, Mengyun Zhang, Qi Zhang, Lijuan Liu, Xiaofei Liu, Yang Geng, Jinyong Wang*, Yu Lan*. Co-Expression of Runx1, Hoxa9, Hlf, and Hoxa7 Confers Multi-Lineage Potential on Hematopoietic Progenitors Derived From Pluripotent Stem Cells. Frontiers in Cell and Developmental Biology. 2022 Apr 28;10:859769. (PMID: 35573697. DOI: 10.3389/fcell.2022.859769) Epub 2022-04-28 (2021 IF=6.081)
3.Siyuan Hou#, Zongcheng Li#, Ji Dong#, Yun Gao#, Zhilin Chang#, Xiaochen Ding#, Shuaili Li, Yunqiao Li, Yang Zeng, Qian Xin, Baihan Wang, Yanli Ni, Xiaowei Ning, Yuqiong Hu, Xiaoying Fan, Yu Hou, Xianlong Li, Lu Wen, Bin Zhou, Bing Liu*, Fuchou Tang*, Yu Lan*. Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals. Cell Research. 2022 Apr;32(4):333-348. (PMID: 35079138. DOI: 10.1038/s41422-022-00615-z) Epub 2022-01-25 (2021 IF=46.297)
4.Yu Lan*. Deciphering the continuum of hemogenic endothelium differentiation. Blood. 2022 Jan 20;139(3):308-310. (PMID: 35050334. DOI: 10.1182/blood.2021013853) Epub 2022-01-20 (2021 IF=25.476)
5.Chen C Li#, Guangyu Zhang#, Junjie Du, Di Liu, Zongcheng Li, Yanli Ni, Jie Zhou, Yunqiao Li, Siyuan Hou, Xiaona Zheng, Yu Lan*, Bing Liu*, Aibin He*. Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos. Nature Communications. 2022 Jan 17;13(1):346. (PMID: 35039499. DOI: 10.1038/s41467-022-28018-z) Epub 2022-01-17 (2021 IF=17.694)
6.Fang Wang#, Puwen Tan#, Pengcheng Zhang#, Yue Ren#, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Science Advances. 2022 Jan 7;8(1):eabg5369. (PMID: 34995116. DOI: 10.1126/sciadv.abg5369) Epub 2022-01-07 (2021 IF=14.957)
7.Chaojie Wang#, Yandong Gong#, Anbang Wei#, Tao Huang, Siyuan Hou, Junjie Du, Zongcheng Li, Junliang Wang, Bing Liu*, Yu Lan*. Adult-repopulating lymphoid potential of yolk sac blood vessels is not confined to arterial endothelial cells. Science China-Life Sciences. 2021 Dec;64(12):2073-2087. (PMID: 34181164. DOI: 10.1007/s11427-021-1935-2) Epub 2021-06-23 (2021 IF=10.372)
8.Xiaofang Wang#, Yanjuan Chen#, Zongcheng Li#, Bingyan Huang, Ling Xu, Jing Lai, Yuhong Lu, Xianfeng Zha, Bing Liu, Yu Lan*, Yangqiu Li*. Single-Cell RNA-Seq of T Cells in B-ALL Patients Reveals an Exhausted Subset with Remarkable Heterogeneity. Advanced Science. 2021 Oct;8(19):e2101447. (PMID: 34365737. DOI: 10.1002/advs.202101447) Epub 2021-08-08 (2021 IF=17.521)
9.Chen Liu#, Yandong Gong#, Han Zhang#, Hua Yang#, Yang Zeng, Zhilei Bian, Qian Xin, Zhijie Bai, Man Zhang, Jian He, Jing Yan, Jie Zhou, Zongcheng Li, Yanli Ni, Aiqing Wen*, Yu Lan*, Hongbo Hu*, Bing Liu*. Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells. Cell Research. 2021 Oct;31(10):1106-1122. (PMID: 34239074. DOI: 10.1038/s41422-021-00529-2) Epub 2021-07-08 (2021 IF=46.297)
10.Hui Shi#, Han He#, Lei Cui#, Egle Kvedaraite#, Zhilei Bian#, Tao Huang#, Christopher Z. W. Lee, Zhigang Li, Jian He, Yandong Gong, Zongcheng Li, Jie Zhou, Yang Zeng, Xianlong Li, Yanli Ni, Zhijie Bai, Chen Liu, Na Li, Honghao Ma, Dong Wang, Yu Lan*, Florent Ginhoux*, Rui Zhang*, Bing Liu*. Transcriptomic Landscape of Circulating Mononuclear Phagocytes in Langerhans Cell Histiocytosis at Single-cell Level. Blood. 2021 Oct 7;138(14):1237-1248. (PMID: 34132762. DOI: 10.1182/blood.2020009064) Epub 2021-06-16 (2021 IF=25.476)
11.Xianlong Li#, Di Liu#, Linlin Zhang, Haizhen Wang, Yunqiao Li, Zongcheng Li, Aibin He, Bing Liu, Jie Zhou*, Fuchou Tang*, Yu Lan*. The comprehensive DNA methylation landscape of hematopoietic stem cell development. Cell Discovery. 2021 Sep 21;7(1):86. (PMID: 34545065. DOI: 10.1038/s41421-021-00298-7). Epub 2021-09-21 (2021 IF=38.079)
12.Wanbo Tang, Jian He, Tao Huang, Zhijie Bai, Chaojie Wang, Haizhen Wang, Ruichuang Yang, Yanli Ni, Jun Hou, Junliang Wang, Jie Zhou, Yingpeng Yao, Yandong Gong, Siyuan Hou, Bing Liu*, Yu Lan*. Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate. Frontiers in Cell and Developmental Biology. 2021 Sep 13;9:728057. (PMID: 34589491. DOI: 10.3389/fcell.2021.728057) Epub 2021-09-13 (2021 IF=6.081)
13.Yun-Qiao Li, Yandong Gong, Siyuan Hou, Tao Huang, Haizhen Wang, Di Liu, Yanli Ni, Chaojie Wang, Junliang Wang, Jun Hou, Ruichuang Yang, Jing Yan, Guangyu Zhang, Bing Liu*, Yu Lan*. Spatiotemporal and Functional Heterogeneity of Hematopoietic Stem Cell-Competent Hemogenic Endothelial Cells in Mouse Embryos. Frontiers in Cell and Developmental Biology. 2021 Aug 11;9:699263. (PMID: 34458261. DOI: 10.3389/fcell.2021.699263) Epub 2021-08-11 (2021 IF=6.081)
14.Zhilei Bian#, Yandong Gong#, Tao Huang#, Christopher Z. W. Lee#, Lihong Bian#, Zhijie Bai#, Hui Shi#, Yang Zeng, Chen Liu, Jian He, Jie Zhou, Xianlong Li, Zongcheng Li, Yanli Ni, Chunyu Ma, Lei Cui, Rui Zhang, Jerry K. Y. Chan, Lai Guan Ng, Yu Lan*, Florent Ginhoux*, Bing Liu*. Deciphering Human Macrophage Development at Single Cell Resolution. Nature. 2020 Jun;582(7813):571-576. (PMID: 32499656. DOI: 10.1038/s41586-020-2316-7) Epub 2020-05-20 (2020 IF=49.962)
15.Siyuan Hou#, Zongcheng Li#, Xiaona Zheng#, Yun Gao#, Ji Dong#, Yanli Ni#, Xiaobo Wang, Yunqiao Li, Xiaochen Ding, Zhilin Chang, Shuaili Li, Yuqiong Hu, Xiaoying Fan, Yu Hou, Lu Wen, Bing Liu*, Fuchou Tang*, Yu Lan*. Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses. Cell Research. 2020 May;30(5):376-392. (PMID: 32203131. DOI: 10.1038/s41422-020-0300-2) Epub 2020-03-20 (2020 IF=25.617)
16.Yang Zeng#, Chen Liu#, Yandong Gong#, Zhijie Bai#, Siyuan Hou#, Jian He, Zhilei Bian, Zongcheng Li, Yanli Ni, Jing Yan, Tao Huang, Hui Shi, Chunyu Ma, Xueying Chen, Jinyong Wang, Lihong Bian, Yu Lan*, Bing Liu*, Hongbo Hu*. Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos. Immunity. 2019 Nov 19;51(5):930-948.e6. (PMID: 31604687. DOI: 10.1016/j.immuni.2019.09.008) Epub 2019-10-08 (2019 IF=22.553)
17.Yang Zeng#, Jian He#, Zhijie Bai#, Zongcheng Li#, Yandong Gong, Chen Liu, Yanli Ni, Junjie Du, Chunyu Ma, Lihong Bian, Yu Lan*, Bing Liu*. Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing. Cell Research. 2019 Nov;29(11):881-894. (PMID: 31501518. DOI: 10.1038/s41422-019-0228-6) Epub 2019-09-09 (2019 IF=20.507)
18.Jie Zhou#, Jiayue Xu#, Linlin Zhang#, Siqi Liu#, Yanni Ma#, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined single-cell profiling of lncRNAs and functional screening reveals H19 is pivotal for embryonic hematopoietic stem cell development. Cell Stem Cell. 2019 Feb 7;24(2):285-298.e5. (PMID: 30639035. DOI: 10.1016/j.stem.2018.11.023) Epub 2019-01-10 (2019 IF=20.860)
19.Yu Lan*. Procr+ stem cells: from vessel to blood. National Science Review. 2017;4:523-524. (PMID: not available. DOI: 10.1093/nsr/nwx104) 2017-07 (2017 IF=9.408)
20.Hui Ye#, Xiaobo Wang#, Zongcheng Li, Fan Zhou, Xianlong Li, Yanli Ni, Weijing Zhang, Fuchou Tang, Bing Liu*, Yu Lan*. Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence. Cell Research. 2017 Aug;27(8):1065-1068. (PMID: 28452344. DOI: 10.1038/cr.2017.64) Epub 2017-04-28 (2017 IF=15.393)
中国生理学会，血液生理学专业委员会，委员
中国病理生理学会，实验血液学专业委员会，委员
