病理学与病理生理学 副教授
职称：副教授
学科专业：病理学与病理生理学
研究方向：炎症和肿瘤转移、耐药、外泌体液态活检和个体化肿瘤治疗
电子邮箱：luellawang@ 163.com
个人简介：
太阳城集团基础医学院副教授，太阳城集团附属第一医院博士后。研究方向：我国高发恶性肿瘤的诊治的转化研究和应用，包括外泌体液体活检和免疫治疗。在研究领域一流期刊发表多篇学术论文，以第一作者发表SCI收录文章8篇，包括TOP期刊PNAS、Oncogene、Cancer Letters等，其中单篇最高他引次数将近60次。主持国家自然科学基金1项、省部级课题1项、中国博士后基金1项，参与了多项国家自然科学基金。2020年获得广东省科技进步奖二等奖1项。
2015/09-2019/07，汕头大学，病理学与病理生理学，博士
2013/07-2015/08，汕头大学，病理学与病理生理学，硕士
2008/09-2013/06, 南华大学，预防医学，学士
2019/07-2021/12，太阳城集团，第一附属医院，博士后;
2022/01-至今，太阳城集团，太阳成集团tyc539官网
1.Wang L#, Liang D, Xiong X, Lin Y, Zhu J, Yao Z, Wang S, Guo Y, Chen Y,Geary K, Pan Y, Zhou F, Gao S, Zhang D, Yeung SJ, Zhang H*. Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Oncogene 2021 Mar;40(11) .
2.Lu Wang#, Xiao Xiong, Zhimeng Yao, Jianlin Zhu, Yusheng Lin, Wan Lin, Kai Li, Xiaozheng Xu, Yi Guo, Yuping Chen, Yunlong Pan, Fuyou Zhou, Jun Fan, Yan Chen, Shegan Gao*, Sai-Ching Jim Yeung and Hao Zhang*. Chimeric RNA ASTN2-PAPPAas aggravates tumor progression and metastasis in human esophageal cancer. Cancer Lett, 2021 Mar 31;501:1-11.
3.Wang L#, Li K#, Lin X#, Yao Z, Wang S, Xiong X, Ning Z, Wang J, Xu X, Jiang Y, Liu D, Chen Y, Zhang D, Zhang H*: Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis. Cancer Lett, 2019, 450: 22-31
4.Xiong X#, Ke X#, Wang L#, Yao Z, Guo Y, Zhang X, Chen Y, Pang CP, Schally AV*, Zhang H*: Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target. Proc Natl Acad Sci USA, 2020, 117(12): 6726-6732
5.Du L#, Wang L#, Gan J#, Yao Z, Lin W, Li J, Guo Y, Chen Y, Zhou F*, Jim Yeung SC, Coppes RP, Zhang D, Zhang H*: MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis. iScience, 2019, 22: 353-368
6.Wang L#, Li W#, Li K#, Guo Y, Liu D, Yao Z, Lin X, Li S, Jiang Z, Liu Q, Jiang Y, Zhang B, Chen L, Zhou F, Ren H, Lin D, Zhang D, Yeung SJ, Zhang H*: The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma. Cancer Med, 2018, 7(10): 5205-5216
7.Zheng L#, Wang L#, Gan J, Zhang H*: RNA activation: promise as a new weapon against cancer. Cancer Lett, 2014, 355(1): 18-24
8.Zhang Y#, Ren H#, Wang L#, Ning Z, Zhuang Y, Gan J, Chen S, Zhou D, Zhu H, Tan D, Zhang H*: Clinical impact of tumor-infiltrating inflammatory cells in primary small cell esophageal carcinoma. Int J Mol Sci 2014 May 30;15(6)
9.Zhu J#, Wang L#, Liu F, Pan J, Yao Z, Lin Y, Yang Y, Xiong X, Li K, Yang Y, Zhang Y, Chu X, Pan Y*, Zhang H*: Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer. Cancers (Basel) 2022 Jan 13;14(2)
广东省科学技术奖科技进步奖，二等奖，名称：食管癌肿瘤标志物及液体活检的应用与开发，排名第二
