贾红玲

医学生物化学与分子生物学系 高级实验师

个人简介


职称:高级实验师

学科专业:生物化学与分子生物学

研究方向:

1.重大病毒性传染病的致病机制,变异及进化,传播关系的分析工作等

2.儿童心脏病的基础研究

电子邮箱:thongling@jnu.edu.cn

个人简介:贾红玲,太阳成集团tyc539官网,硕士研究生导师,广州市疾病预防控制中心特聘专家,主要从事重大病毒性传染病和儿童心脏病领域的基础研究,以第一作者或通讯作者(含共同)发表 SCI 论文 23篇,其中4篇1区TOP期刊文章,单篇文章影响因子达到38.1。近年来主持国家自然科学基金2 项,广东省自然科学基金 1 项,太阳城集团横向课题 4项,国际专利授权1项,国内专利授权2项。


学习科研经历


1994 年 9 月~1998 年 7 月 石河子大学,动物医学专业,学士学位

2005 年 9 月~2008 年 7 月 中国科学院微生物研究所/甘肃农业大学,预防动物医学专业,硕士学位

2015 年 9 月~2018 年 7 月 华南农业大学,基础动物医学专业,博士学位

1998 年 7 月~2005 年 8 月 新疆阜康市畜牧局城关兽医站,禽流感监测和检测专家成员。

2008 年 7 月~至今 太阳成集团tyc539官网,高级实验师


主要论文


1. Hui Wang, Yuqi Liu, Peng Li, Chaowu Liu, Kuibiao Li, Lan Cao, Ying Zhang, Zichun Cheng, Kailing Huang, Zhouxia Zheng, Xiaoqian Xin, Yifeng Liu, Xiaofang Peng, Dan Liang, Bixia Ke, Tao Wang, Qingpei Chen, Weihua Luo, Chaolang Qin, Lihong Sun, Guobing Chen, Oscar Junhong Luo, Jixi Li, Qiao Zhang, Biao Di, Zhoubin Zhang*, Changwen Ke*, Hongling Jia*, Feng Gao*.Emergence of epidemic variants of SARS-CoV-2 by acquiring combinations of new highly mutable nucleotides in its genome. J Infect. 2023, 86(6):588-592. (共同通讯作者)

2. Wei Zhou, Hua Zhang, Lihua Huang, Chuankai Sun, Yuhan Yue, Xiaolei Cao, Hongling Jia*, Chunyue Wang*, Yunfei Gao*. Disulfiram with Cu2+ alleviates dextran sulfate sodium-induced ulcerative colitis in mice. Theranostics. 2023, 13(9):2879-2895. (共同通讯作者)

3. Biao Di†, Hong-ling Jia†, Oscar Jun-hong Luo†, Fang-qin Lin†, Kui-biao Li†, Yuan-liang Zhang, Hua-dong Wang, Hui-ying Liang*, Jun Fan*, Zhicong Yang*. Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics. Signal Transduct Target Ther. 2020, 5(1):217. (并列第一作者)

4. Hong-Ling Jia†, Chao-Wu Liu†, Dan-Tong Li†, Qing-Sheng Huang†, Dong Liu†, Ying Zhang†, Chang Ye, Di Zhou, Yang Wang, Yan-Lian Tan, Kui-Biao Li, Fang-Qin Lin, Hai-Qing Zhang, Jing-Chao Lin, Yang Xu, JingWen Liu, Qing Zeng, Jian Hong, Guo-Bing Chen, Hao Zhang, Ling-Ling Zheng, Xi-Long Deng, Chang-Wen Ke, Yun-Fei Gao*, Jun Fan*, Biao Di*, Hui-Ying Liang*. Metabolomic analyses reveals new stage-specific features of the COVID-19. Eur Respir J, 2022, 59(2):2100284.(第一作者).

5. Hongling Jia†, Hui Wang†, Lan Cao†, Zhisheng Lai†, Zichun Cheng, Qingpei Chen, Tongzheng Liu, Xiangyi Liu, Yanting Wen, Conghui Xu, Weizhi Lu, Guang Yang, Deqian Zhou, Biao Di*, Feng Gao*, Zhicong Yang*. Genetic analysis of a SARS-CoV-2 Omicron variant from a Chinese traveller returning from overseas. Emerg Microbes Infect. 2022;11(1):306-309.(第一作者)

6. Hong-Ling Jia†, Peng Li†, Hong-Jie Liu†, Jia-Yong Zhong†, Peng-Zhe Qin†, Wen-Zhe Su, Ying-Feng Zheng, Kui-Biao Li, Qing Zeng, Jin-Hui Li , Li-Zhong Li, Lan Cao, Ji-Bin Wu, Yi-Yun Chen, Lei-Li Jia, HongBin Song, Qi-Wei Zhang, Guang Yang, Chun-Xia Jing, Xiao-Chen Bo, Zhou-Bin Zhang, Biao Di*, Chuan-Le Xiao*, Ming Ni*. Genomic elucidation of a COVID-19 resurgence and local transmission of SARS-CoV-2 in Guangzhou, China. J Clin Microbiol. 2021, 59(8):e0007921. doi: 10.1128/JCM.00079-21.(第一作者)

7. Hua Zhang†, Renwen Zhang†, Xujia Zeng, Xiao Wang, Desheng Wang, Hongling Jia*, Weiguo Xu*, Yunfei Gao*. Exposure to neonicotinoid insecticides and their characteristic metabolites: Association with human liver cancer. Environ Res. 2022, 208:112703. doi: 10.1016/j.envres.2022.112703.(共同通讯作者)

8. Ming-Guo Xu†, Qi Qi†, Li-Na.,Men†, Shu-shui,Wang†, Meng Li, Min Xiao, Xiai-Zhou Chen, Seng Wang, Guo-Bin.Wang, Hong-ling Jia* and Cong Liu*. Berberine protects Kawasaki disease-induced human coronary artery endothelial cells dysfunction by inhibiting of oxidative and endoplasmic reticulum stress. Vascul Pharmacol. 2020, 127: 106660.(共同通讯作者)

9.  Bo-Ning Li†, Quan-Dong Tang†, Yan-Lian Tan†, Liang Yan, Ling Sun, Wei-Bing Guo, Ming-Yang Qian, Allen Chen, Zhou-Xia Zheng, Zhi-Wei Zhang*, Hong-Ling Jia*, Cong Liu*. Key Regulatory Differentially Expressed Genes in the Blood of Atrial Septal Defect Children Treated With Occlusion Devices. Front. Genet., 2021, doi.org/10.3389/fgene.2021.790426.(共同通讯作者)

10. Yan-Fei Wang†, Xin-Lei Lian†, Jia-Yong Zhong†, Shi-Xin Su, Yu-Fen Xu, Xiao-Fei Xie, Zhou-Ping Wang, Wei Li, Li Zhang, Di Che, Li Yu, Ping Huang*, Hong-Ling Jia*, Xiao-Qiong Gu*. Serum exosomal microRNA Let-7i-3p as candidate diagnostic biomarker for Kawasaki Disease patients with coronary artery aneurysm. IUBMB Life. 2019, doi: 10.1002/iub.2015(共同通讯作者)

11. Chao-Wu Liu†, De-Guang Yang†, Hong Wang†, Sheng-Wei Hu, Xiao-Fei Xie, Li Zhang, Hong-Ling Jia*, Qi Qi* . MicroRNA-197-3p mediates damage to human coronary artery endothelial cells via targeting TIMP3 in Kawasaki disease. Mol Cell Biochem. 2021, doi: 10.1007/s11010-021-04238-7.(共同通讯作者)

12. Shui-Ming Li†, Wan-Ting Liu†, Fang Yang, Qi-Jian Yi*, Shuai Zhang*, Hong-Ling Jia*. Phosphorylated Proteomics Analysis of Human Coronary Artery Endothelial Cells Stimulated by Kawasaki Disease Patients Serum. BMC Cardiovasc Disor. 2019, 19(1):21. doi: 10.1186/s12872-018-0982-2.(通讯作者) 

13. Hong-Ling Jia†, Xiao-Qin Zeng†, Feng Huang†, Ya-Meng Liu, Bi-Shuang Gong, Kai-Zhao Zhang,Jiang-Hui Zeng, Dong-Guang Guo, Zhuo-Ya Wang*, Yu-Gu Li*. Integrated microRNA and mRNA sequencing analysis of age-related changes to mouse thymic epithelial cells. IUBMB Life. 2018, 70(7):678-690. doi: 10.1002/iub.1864.(第一作者)

14. Wan-Ting Liu†, Chao-Wu Liu†, Li Zhang†, Xiao-Fei Xie, Xiao-Qiong Gu, Chuan-Lan Sang, Ming-Guo Xu*, Wei-Jun Xu, Hong-Ling Jia*. Molecular Basis of Coronary Artery Dilation and Aneurysms in Patients with Kawasaki Disease Based on Differential Protein Expression. Mol Med Rep. 2018, 17(2):2402-2414. doi: 10.3892/mmr.2017.8111. (通讯作者)

15. Xiao-Fei Xie†, Hong-Juan Chu†, Yu-Fen Xu, Liang Hua, Zhou-Ping Wang, Ping Huang, Hong-Ling Jia*, Li Zhang*. Proteomics study of serum exosomes in Kawasaki disease patients with coronary artery aneurysms. Cardiol J. 2018, doi: 10.5603/CJ.a2018.0032. (共同通讯作者)

16. Hong-Ling Jia†, Chao-Wu Liu†, Li Zhang*, Wei-Jun Xu†, Xue-Juan Gao, Jun Bai, Yu- Fen Xu,Ming-Guo Xu*,Gong Zhang*.Sets of serum exosomal microRNAs as candidate diagnostic biomarkers for Kawasaki disease. Sci Rep. 2017, 20;7:44706. doi: 10.1038/srep44706.(第一作者)

17. Li Zhang†, Qi-Fang Song†, Jin-Jie Jin†, Ping Huang, Zhou-Ping Wang, Xiao-Fei Xie, Xiao-Qiong Gu, Xue-Juan Gao*, Hong-Ling,Jia*. Differential protein analysis of serum exosomes post-intravenous immunoglobulin therapy in patients with Kawasaki disease. Cardiol Young.2017, 27(9):1786-1796. (通讯作者)

18. Li Zhang†, Wei Wang†, Jun Bai†, Yu-Fen, Xu,Lai-Qing Li, Liang Hua, Li Deng*, Hong-Ling Jia*.Proteomic analysis associated with coronary artery dilatation caused by Kawasaki disease using serum exosomes. Rev Port Cardiol. 2016, 35(5):265-273.  (通讯作者)

19. Li Zhang†, Hong-Ling Jia†,Wei-Min Huang†, Chao-Wu Liu, Liang Hua, Te-Chang Liu, Li-Jia Mao, Yu-Fen Xu, Wei Li, Shu-Liang Xia, Ying-Yan Gan, Li Deng*, Gong Zhang*. Monitoring of the serum proteome in Kawasaki disease patients before and after immunoglobulin therapy. Biochem Biophys Res Commun. 2014, 4471:19~25. (并列第一作者)

20. Xiao-Hong Wang†, Hong-Ling Jia†, Li Deng, Wei-Min Huang*. Astragalus polysaccharides mediated preventive effects on bronchopulmonary dysplasia in rats. Pediatr Res. 2014, 76(4):347-354.(并列第一作者) 

21. Hong-Ling Jia†, Chun-Hui He†, Zhuo-ya Wang, Yu-Fen Xu, Gen-Quan. Yin, Li-Jia Mao, Chao-Wu Liu*, Li Deng*. MicroRNA expression profile in exosome discriminates extremely severe infections from mild infections for hand, foot and mouth disease. BMC Infect Dis. 2014, 14:506. doi: 10.1186/1471-2334-14-506. (第一作者)

22. Li Deng†, Hong-Ling Jia†, Chao-Wu Liu†, Yu-Fen Xu, Li-Jia Mao, Chun-Hui He, Gen-Quan Yin, Jun-Hong Lin,Jian-Ping Tao and Li Zhu*. Proteomic analysis of extremely severe hand, foot and mouth disease infected by enterovirus 71. BMC Infect Dis. 2013, 383(13): doi: 10.1186.(并列第一作者)

23. Li. Deng†, Hong-Ling Jia†, Chao-Wu. Liu†, Kun-Hua. Hu, Gen-Quan. Yin, Jia-Wei. Ye, Chun-Hui He, Jia-Hui. Chen, Ya-Ping. Xie, Run Dang, Lin Zhang, Nu-Yun Liu, Li Zhu* and Lu Zhang*. Analysis of differentially expressed proteins involved in hand, foot and mouth disease and normal sera. Clin Microbiol Infect. 2012, 18(6):E188-96.(并列第一作者)

24. Xue-Song Sun†, Hong-Ling Jia†, Chuan-Le Xiao, Xing-Feng Yin, Xiao-Yan Yang, Jie Lu, Xiang He, Hui Li. Bacterial proteome of streptococcus pneumoniae through multidimensional separations coupled with LC-MS/MS. OMICS, 2011, 15(7-8):477-482(并列第一作者)

25. Hong-Ling Jia†,Chao-Wu Liu†, Feng Ge, Chuan-Le Xiao C, Chun-Hua Lu, Tong Wang*. Identification of ubiquitinated proteins from human multiple myeloma U266 cells by proteomics. Biomed Environ Sci, 2011, 24(4):422-430.(第一作者) 


学术著作


参编生物化学与分子生物学实验教材


获奖及荣誉