生物医学转化研究院 副研究员 招生方向：免疫学
研究方向：
1.肠道微生物与免疫系统的相互调控；
2.代谢性疾病的免疫机制；
3.基于转基因动物疾病模型的小分子药物筛选。
个人简介：
杨恒文博士，2001年毕业于清华大学生物科学与技术系，获生物学学士学位；2007年获清华大学生物科学与技术系生物化学与分子生物学博士学位。随后赴美国克罗拉多大学博尔德分校从事博士后研究，回国后加入太阳城集团生物医学转化研究院尹芝南经理团队，任副研究员，博士生导师。主要研究肠道微生物与免疫在精神、代谢等重要疾病中的作用及其分子机制，研究成果发表在Nature、Nature communications、Cell Discovery等杂志；主持国自然面上项目等多个项目，参与教育部提名国家科学技术奖自然科学一等奖一项，广东省自然科学进步一等奖一项；担任广东省免疫学会理事，中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员，中国生物物理学会肠道菌群分会委员。
联系方式：
电子邮箱：hengwenyang@jnu.edu.cn
地址：太阳城集团北门梁仲景楼8楼808
1. IL-27 signaling promotes adipocyte thermogenesis and energy expenditure. Qian Wang#, Dehai Li#, Guangchao Cao#, Qiping Shi#, Jing Zhu, Mingyue Zhang, Hao Cheng , Qiong Wen , Hao Xu , Leqing Zhu , Hua Zhang , Rachel Perry , Olga Spadaro , Yunfan Yang , Shengqi He , Yong Chen , Baocheng Wang , Guangqiang Li , Zonghua Liu , Caixian Yang , Xiaoli Wu , Libing Zhou , Qinghua Zhou , Zhenyu Ju , Hongyun Lu , Yongjie Xin , Xiaoyong Yang , Cunchuan Wang , Yong Liu , Gerald Shulman , Vishwa Dixit , Ligong Lu*, Hengwen Yang*, Richard A. Flavell*, Zhinan Yin*. Nature, 2021, Nov 24. doi: 10.1038/s41586-021-04127-5.
2. Roux-en-Y Gastric Bypass improved insulin resistance via alteration of the human gut microbiome and alleviation of endotoxemia. Qiping Shi#, Qian Wang#, Hui Zhong, Dehai Li, Shuxing Yu, Hengwen Yang*, Cunchuan Wang*, Zhinan Yin*, BioMed Research International. 2021
3. Metabolic Control of γδ T Cell Function. Meng Z#, Cao G#, Yang Q#, Yang H*, Hao J*, Yin Z*. Infect Microb Dis 2021;00(00):00–00. doi: 10.1097/ IM9.0000000000000054
4. Perforin Acts as An Immune Regulator to Prevent NAFLD Progression. Qian Wang#*, Dehai Li#, Jing Zhu#, Mingyue Zhang, Hua Zhang, Guangchao Cao, Leqing Zhu, Qiping Shi, Jianlei Hao, Qiong Wen, Zonghua Liu, Hengwen Yang* and Zhinan Yin*. Front. Immunol. May 2020, Volume 11, Article 846, doi: 10.3389/ fimmu.2020.00846
5. Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2. Qin-Li Wan#, Xiaodie Fu#, Wenyu Dai, Jing Yang, Zhenhuan Luo, Xiao Meng, Xiao Liu, Ruowei Zhong, Hengwen Yang*, Qinghua Zhou*. AGING 2020, 12(3):2840-2853
6. Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity. Jing Zhu#, Ruitian Cai#, Yuxiang Tan#, Xiuqing Wu, Qiong Wen, Zonghua Liu, Shu-Hua Ouyang, Zhinan Yin*, Hengwen Yang*. Journal of Functional Foods，Volume 64, January 2020, 103621
7. Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals. Qin‐Li Wan#, Xiao Meng#, Xiaodie Fu#, Bohui Chen, Jing Yang,Hengwen Yang*, Qinghua Zhou*, AGING, 2019 Jun 21;11(12):3993-4010
8. NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer. Li Z#, Tang X#, Luo Y, Chen B, Zhou C, Wu X, Tang Z, Qi X, Cao G, Hao J, Liu Z, Wang Q, Yin Z, Yang H*. J Cell Physiol. 2019 Feb 20. 234(9):16178–16190. doi: 10.1002/jcp.28278.
9. Gut microbiota have blood types as human. Qizheng Wu#, Hui Zhong#, Yafei Zhai, Yanjiong Jia, Zhinan Yin, Min Chen*, Hengwen Yang*, Peng George Wang*. Sci Bull 63 (2018) 1311–1313,
10. Transmembrane domain dependent inhibitory function of FcγRIIB. Wang J, Li Z, Xu L*, Yang H*, Liu W*. Protein Cell. 2018 Dec;9(12):1004-1012. doi: 10.1007/s13238-018-0509-8.
11. Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice. Guangchao Cao#, Qian Wang#, Wanjun Huang#, Jiyu Tong, Dewei Ye, Yan He, Zonghua Liu, Xin Tang, Hao Cheng, Qiong Wen, Dehai Li, Hau-Tak Chau, Yiming Wen, Hui Zhong, Ziyu Meng, Hui Liu, Zhenzhou Wu, Liqing Zhao, Richard A Flavell, Hongwei Zhou, Aimin Xu, Hengwen Yang*, Zhinan Yin*. Cell Discovery (2017) 3, 17020; doi:10.1038/celldisc.2017.20
12. Remodeling of the gut microbiota and structural shifts in Preeclampsia patients in South China. Liu J#, Yang H#, Yin Z, Jiang X, Zhong H, Qiu D, Zhu F, Li R. Eur J Clin Microbiol Infect Dis. 2017 Apr;36(4):713-719, doi: 10.1007/s10096-016-2853-z.
13. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Yang Hengwen#, Chen YZ#, Zhang Y#, Wang X, Zhao X, Godfroy JI 3rd, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. Nature Communications, 6(1), 1-12. 2015 Jan 7.
14. Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure. Chao L#, Lu L#, Yang Hengwen#, Zhu Y, Li Y, Wang Q, Yu X, Jiang S, Chen YH*.PLoS One. 2013 May 31;8(5): e66156.
15. Evidence for existence of a close association between CD14 and CXCR4 on monocytic cell line U937. Hengwen Yang, Canhui Lan, Ying-Hua Chen. Porgress in Natural Science. 2007
16. Antibody to CD14 like CXCR4-specific antibody 12G5 could inhibit CXCR4-dependent chemotaxis and HIV Env-mediated cell fusion. Hengwen Yang, Canhui Lan, Yi Xiao, Ying-Hua Chen. Immunol Lett. 2003, 88 (1): 27-30.
17. Characterization of interaction between C-domain on HIV-1 gp41 and the putative receptor protein p62. Hengwen Yang, Yi Xiao, Yun Lu, Ying-Hua Chen. Immunobiology. 2001, 203: 778-785.
广东省免疫学会理事
中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员
中国生物物理学会肠道菌群分会委员
